Posts tagged transposon
Lying dormant in our genomes are millions of jumping genes. Originally discovered by Barbara McClintock, transposons are DNA sequences that can move from one location to another in our DNA. Transposons cause mutations when they jump to new locations, so keeping them from jumping is important. However, although transposons are largely silent, every person probably has a few “rare” sites, found in only a few people in the world, where a transposon has jumped to a new location.
Mobile chunks of DNA that walk their way from one position in the genome to another may affect neurological diseases and could have subtle influences on normal brain function and behavior, according to a recent study in Nature.
Alu is an example of a so-called “jumping gene” – a transposable DNA sequence that “reproduces” by copying itself and inserting into new locations throughout the genome. Alu elements are classified as SINEs, or Short INterspersed Elements. All Alus are approximately 300 bp in length and derive their name from a single recognition site for the restriction enzyme AluI located near the middle of the Alu More >