A 2003, a paper by Caspi and colleagues offered tantalizing clues about the genetics of depression, in what was widely-acclaimed as a breakthrough paper for psychiatric genetics as a whole. Now, new research by Katleeen Merikangas at the National Institute of Mental Health queries the results taking us, according to Science magazine, back to the drawing board.

What was so important about Caspi et al.? The original Caspi paper of 2003 looked at a sample of 847 New Zealanders, and examined whether gene-environment interactions might lead to depression. The research team were particularly interested in genes involved in serotonin transportation and reception - serotonin has More >