Posts tagged HNSCC
HPV twist?
Nov 17th
Human Papilloma Virus (HPV) is a family of small, non-enveloped DNA viruses which infect epithelial cells, and of which there are over 100 subtypes. HPV is divided into two major categories, high risk types which includes types 16, 18, 31. 33, 35. 39, 45, and low risk types 6 and 11. HPV 16 is implicated in over 90% of cervical cancers and shown to be a causal factor in the development of the disease. HPV produces two oncoproteins, E6 and E7, which inactivate the cellular tumor suppressor proteins, p53 and pRB respectively. This allows it to disable two of the More >