Ever had the feeling you have lost your marbles?  According to the Phrase Finder that expression has conveyed a sense of loss, anger, and more recently a lack of common sense or sanity. As it turns out it may be the loss of certain segments of DNA (rather than simple mutations like SNPs) that may have a lot to do with the origins of mental illnesses like schizophrenia.

Now before you start thinking that schizophrenics are the only ones to lose their marbles (or large sections of their genomes), It has been previously shown by work like that of Jonathan Sebat of More >