Unfortunately very little is known about how this disease develops, so a new breakthrough published in Neuron (and by a second group also in Neuron) is reason for hope. Work by two independent groups uncovered a locus on chromosome 9 (actually an expansion of repetitive DNA in a non-coding region called C9ORF72) is implicated in at least a third of ALS cases. This sequence variation seems to affect the cells ability to recycle and cope with damaged proteins; when these proteins fail to be properly processed, the cell is damaged an ALS is the result. While this research may not explain all the causes of ALS, it is an important landmark in the battle against this illness, and provides a target for future research and therapeutic intervention.