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	<title>DNALC Blogs &#187; heritability</title>
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	<link>http://blogs.dnalc.org</link>
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		<title>Eliminating Undesirable Traits</title>
		<link>http://blogs.dnalc.org/2010/02/18/eliminating-undesirable-traits/</link>
		<comments>http://blogs.dnalc.org/2010/02/18/eliminating-undesirable-traits/#comments</comments>
		<pubDate>Thu, 18 Feb 2010 16:52:59 +0000</pubDate>
		<dc:creator><![CDATA[Susan Lauter]]></dc:creator>
				<category><![CDATA[Eugenics Archive]]></category>
		<category><![CDATA[blindness]]></category>
		<category><![CDATA[eugenics]]></category>
		<category><![CDATA[genetic disease]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Inheritance]]></category>
		<category><![CDATA[Pedigree]]></category>

		<guid isPermaLink="false">http://9.121</guid>
		<description><![CDATA[Eugenics aimed to eliminate undesirable traits. But how do you define &#8220;undesirable&#8221;? There is anecdotal evidence that the incidence of some disorders has decreased due to genetic testing (see &#8220;Testing Curbs Some Genetic Diseases,&#8221; by Marilyn Marchione). In and of itself, this is a good thing, but is this eugenics? It would be hard to&#8230;]]></description>
				<content:encoded><![CDATA[<p><a href="http://blogs.dnalc.org/wp-content/uploads/2010/02/blind_thumb.jpg"><img class="alignleft size-full wp-image-3326" title="blind_thumb" src="http://blogs.dnalc.org/wp-content/uploads/2010/02/blind_thumb.jpg" alt="" width="150" height="150" /></a>Eugenics aimed to eliminate undesirable traits. But how do you define &#8220;undesirable&#8221;? There is anecdotal evidence that the incidence of some disorders has decreased due to genetic testing (<a href="http://www.washingtonpost.com/wp-dyn/content/article/2010/02/17/AR2010021700003.html">see &#8220;Testing Curbs Some Genetic Diseases,&#8221; by Marilyn Marchione</a>). In and of itself, this is a good thing, but is this eugenics? It would be hard to argue that most genetic diseases are undesirable; but some of the steps taken to eliminate disease &#8212; abortion, embryo screening &#8212; are controversial.</p>
<p>In contrast, there was a an effort to prevent hereditary blindness within the eugenics movement. Its proponents <a href="http://www.eugenicsarchive.org/html/eugenics/index2.html?tag=257">collected pedigrees</a>, <a href="http://www.eugenicsarchive.org/html/eugenics/index2.html?tag=264">drafted legislation to prevent marriage</a> of blind individuals, and <a href="http://www.eugenicsarchive.org/html/eugenics/index2.html?tag=329">surveyed ophthalmologists </a>to assess causes of blindness and the cost to society to provide for the blind in specialized homes and schools. Their intent was to eliminate blindness in future generations. However, this <em>was</em> eugenics because affected individuals would not have been allowed to decide for themselves if the trait was undesirable, or what steps to take eliminate it.</p>
<div id="attachment_124" style="width: 406px" class="wp-caption alignright"><a href="http://www.eugenicsarchive.org/html/eugenics/index2.html?tag=257"><img class="size-full wp-image-124" src="/oldimages/blindness_pedigree.jpg" alt="Pedigree of a family with blindness" width="396" height="269" /></a><p class="wp-caption-text">Pedigree of a family with blindness</p></div>
<p>Explore the <a href="http://www.eugenicsarchive.org">Eugenics Archive</a>, especially the &#8220;Hereditary Disorders&#8221; topic, for many examples of how eugenicists viewed inherited diseases.</p>
<p>&nbsp;</p>
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		<title>It’s All Your Parents’ Fault</title>
		<link>http://blogs.dnalc.org/2009/09/15/it%e2%80%99s-all-your-parents%e2%80%99-fault/</link>
		<comments>http://blogs.dnalc.org/2009/09/15/it%e2%80%99s-all-your-parents%e2%80%99-fault/#comments</comments>
		<pubDate>Tue, 15 Sep 2009 17:58:09 +0000</pubDate>
		<dc:creator><![CDATA[Susan Lauter]]></dc:creator>
				<category><![CDATA[Eugenics Archive]]></category>
		<category><![CDATA[eugenics]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Inheritance]]></category>
		<category><![CDATA[traits]]></category>

		<guid isPermaLink="false">http://9.8</guid>
		<description><![CDATA[Eugenicists looked at a diversity of &#8220;traits&#8221; and asserted that many of them were genetically inherited, excluding any other cause. The subjects of the studies often came from unique populations, including circus performers, residents in mental institutions, and even historical figures, long deceased. A quick search in the Eugenics Archive reveals some of the traits&#8230;]]></description>
				<content:encoded><![CDATA[<p>Eugenicists looked at a diversity of &#8220;traits&#8221; and asserted that many of them were genetically inherited, excluding any other cause. The subjects of the studies often came from unique populations, including circus performers, residents in mental institutions, and even historical figures, long deceased.</p>
<p>A quick search in the Eugenics Archive reveals some of the traits studied by Eugenicists:</p>
<p>Civic leadership<br />
Musical ability<br />
Dressmaking<br />
Epilepsy<br />
Dwarfism<br />
Giantism<br />
<img style="margin-left: 20px;" src="http://www.eugenicsarchive.org/images/eugenics/normal/1551-1600/1568-Unfit-Human-Traits-and-Triangle-of-Life.jpg" alt="Eugenics Triangle of Life" width="378" height="306" align="right" />Carpentry<br />
Deafness<br />
Eye color<br />
Insanity<br />
Longevity<br />
Shiftlessness<br />
Cancer<br />
Blindness<br />
Albinism<br />
Hemophilia<br />
Boat building<br />
Degeneracy<br />
Poverty<br />
Feeblemindedness<br />
Cleft palate<br />
Hare lip<br />
Manic depression<br />
Hair color, texture<br />
Polydactyly<br />
Height<br />
Literary ability<br />
Inventiveness<br />
Color blindness<br />
Mechanical skill<br />
Artistic ability<br />
Alcoholism<br />
Thalassophilia (love of the sea)</p>
<p>Eugenicists failed to recognize that not all familial traits are biologically inherited, or that traits that are inherited can have complex causes. They did not consider that in addition to genes, families share customs, work environments, and eating habits that can affect their physical, mental, and emotional development.</p>
<p>Reading over the list, it is evident that Eugenicists were on target with some of their assertions. In my personal experience, my husband has long suffered from Thalassophilia, but my children have yet to express that trait. It must be recessive.</p>
<p>For further exploration:<br />
From the Archive: <a href="http://www.eugenicsarchive.org/html/eugenics/essay4text.html">Traits Studied By Eugenicists by Jan Witkowski, Cold Spring Harbor Laboratory</a><br />
DNAftB Concept 14: <a href="http://www.dnaftb.org/14/concept/index.html">Mendelian genetics cannot fully explain human health and behavior.</a></p>
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		<item>
		<title>Passing on Genes and Traits</title>
		<link>http://blogs.dnalc.org/2009/09/09/passing-on-genes-and-traits/</link>
		<comments>http://blogs.dnalc.org/2009/09/09/passing-on-genes-and-traits/#comments</comments>
		<pubDate>Wed, 09 Sep 2009 23:37:23 +0000</pubDate>
		<dc:creator><![CDATA[Erin McKechnie]]></dc:creator>
				<category><![CDATA[DNA From The Beginning]]></category>
		<category><![CDATA[Education]]></category>
		<category><![CDATA[genotype]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Inheritance]]></category>
		<category><![CDATA[phenotype]]></category>
		<category><![CDATA[teaching]]></category>

		<guid isPermaLink="false">http://5.10</guid>
		<description><![CDATA[Why do you look the way you do? There are many ways to answer this question, but essentially it all comes down to the information in your DNA and the proteins your cells make. Your DNA contains genes that code for proteins. Different proteins have different functions, each contributing to your various traits and functions.&#8230;]]></description>
				<content:encoded><![CDATA[<p><a href="http://blogs.dnalc.org/wp-content/uploads/2009/09/Gene.jpg"><img class="alignleft size-thumbnail wp-image-3142" title="Gene" src="http://blogs.dnalc.org/wp-content/uploads/2009/09/Gene-150x150.jpg" alt="" width="150" height="150" /></a>Why do you look the way you do?  There are many ways to answer this question, but essentially it all comes down to the information in your DNA and the proteins your cells make.  Your DNA contains genes that code for proteins.  Different proteins have different functions, each contributing to your various traits and functions.</p>
<p>Why do we often see similar traits among parents and offspring?  We inherit our DNA from our mother and father.  This means we have half of our genes, or recipes, from our mom and half from our dad.  Even with this basic idea, it can be confusing when we look at traits passed on through generations.  Some terms to help include:</p>
<p>Genotype = the genetic information.</p>
<p>Phenotype = the physical trait expressed in the organism.</p>
<p>How are these terms useful or important?  Let’s use flower color for an example.  If you have a purple flower plant and you cross (mate) it with a while flower plant, what color do you expect to get in the offspring?  You do not have enough information to answer that question.  You were only given the physical traits of the plants, the phenotype.  To accurately predict the color of the offspring you would need to know the genetic background of the parent plants, or their genotype.</p>
<p>It is important to keep in mind that genes do not blend with each other, even though sometimes it seems as though offspring have a blending of traits.   Let’s think about it.  Why is it important that genes do not blend?  Genes are passed on intact from one generation to the next.  This allows for phenotypes, or traits, to be expressed over long periods of time.  If a trait provides an advantage for survival, it will most likely be passed on and accumulate over time.  This process allows for life to continue.  If the genetic information mixed every time offspring formed, we would not be here today.</p>
<p>(***Although genes don’t blend, they can mutate and change.  That will be a topic for next time!)</p>
]]></content:encoded>
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		<item>
		<title>Teaching Genetics: Simplicity for Success</title>
		<link>http://blogs.dnalc.org/2009/09/02/teaching-genetics-simplicity-for-success/</link>
		<comments>http://blogs.dnalc.org/2009/09/02/teaching-genetics-simplicity-for-success/#comments</comments>
		<pubDate>Wed, 02 Sep 2009 16:09:58 +0000</pubDate>
		<dc:creator><![CDATA[Erin McKechnie]]></dc:creator>
				<category><![CDATA[DNA From The Beginning]]></category>
		<category><![CDATA[Education]]></category>
		<category><![CDATA[genetics]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Inheritance]]></category>
		<category><![CDATA[molecular biology]]></category>
		<category><![CDATA[teaching]]></category>

		<guid isPermaLink="false">http://5.7</guid>
		<description><![CDATA[I love to talk about the biology behind how life works with other people. Some of the best conversations I have ever had have been with fifth graders learning about DNA. I am amazed that they know an incredible amount of information relating to genetics, way more than I ever knew when I was their&#8230;]]></description>
				<content:encoded><![CDATA[<p><a href="http://blogs.dnalc.org/wp-content/uploads/2009/09/2129105229_97fa348804.jpg"><img class="alignleft size-thumbnail wp-image-3137" title="2129105229_97fa348804" src="http://blogs.dnalc.org/wp-content/uploads/2009/09/2129105229_97fa348804-150x150.jpg" alt="" width="150" height="150" /></a>I love to talk about the biology behind how life works with other people. Some of the best conversations I have ever had have been with fifth graders learning about DNA. I am amazed that they know an incredible amount of information relating to genetics, way more than I ever knew when I was their age.</p>
<p>I currently teach genetics and molecular biology to middle school students, high school students, teachers, and the general public. One of the greatest skills I have learned in my current position is the importance of engaging your audience and making the material you are introducing easy to understand. Instead of trying to impress people with fancy facts and complex ideas, I was taught to present information in a simple matter.  In my initial observations of my fellow teachers, I was intimidated and thought that everyone around me had to be more intelligent. I heard one teacher describe the DNA in one cell as a cookbook and the genes as recipes. I was shocked at the simplicity of the analogy and went home to compare it with the complicated writing in my old textbooks.  What I found was that the once foreign language of the textbooks was transformed.  Not only could I grasp what they were saying with ease, but I was also able to identify the sections that were poorly explained. I felt empowered and began to search for new ways to describe biology in simple terms.</p>
<p>Getting the facts correct when teaching is equally important as enabling an audience to find a bridge between what they already know and what you are introducing them to. I continue to read about genetics from various resources and try to incorporate as much diversity into my lessons as possible. I enjoy using DNA from the Beginning to describe specific concepts and experiments. I recommend reading the descriptions and the checking out the animations for each section. Also, here are some of my favorite sites for introducing genetics and getting excited about DNA:</p>
<p><a href="http://www.dnai.org/">DNA interactive</a></p>
<p>T<a href="http://www.ornl.gov/sci/techresources/Human_Genome/project/info.shtml">he Human Genome Website: Genetics 101</a></p>
<p><a href="http://www.amnh.org/ology/?channel=genetics">American Museum of Natural History: The Gene Scene</a></p>
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		<item>
		<title>Do Genes Always Follow the Rules?</title>
		<link>http://blogs.dnalc.org/2009/08/31/do-genes-always-follow-the-rules/</link>
		<comments>http://blogs.dnalc.org/2009/08/31/do-genes-always-follow-the-rules/#comments</comments>
		<pubDate>Mon, 31 Aug 2009 19:29:43 +0000</pubDate>
		<dc:creator><![CDATA[Amanda McBrien]]></dc:creator>
				<category><![CDATA[DNA From The Beginning]]></category>
		<category><![CDATA[dna]]></category>
		<category><![CDATA[Education]]></category>
		<category><![CDATA[genes]]></category>
		<category><![CDATA[genetics]]></category>
		<category><![CDATA[heritability]]></category>
		<category><![CDATA[Inheritance]]></category>
		<category><![CDATA[teaching]]></category>

		<guid isPermaLink="false">http://5.3</guid>
		<description><![CDATA[As a teacher, I find that the presentation of classical Mendelian inheritance is important, but can be misleading. Do genes always follow the rules that the &#8220;Father of Genetics&#8221; observed in his garden?  Don’t get me wrong, I appreciate Mendel and his contribution to genetics, but the exceptions seem much more interesting! For example, many&#8230;]]></description>
				<content:encoded><![CDATA[<p><a href="http://blogs.dnalc.org/wp-content/uploads/2009/08/Redhead.jpg"><img class="alignleft size-thumbnail wp-image-3127" title="Redhead" src="http://blogs.dnalc.org/wp-content/uploads/2009/08/Redhead-150x150.jpg" alt="" width="150" height="150" /></a>As a teacher, I find that the presentation of classical Mendelian inheritance is important, but can be misleading. Do genes always follow the rules that the &#8220;Father of Genetics&#8221; observed in his garden?  Don’t get me wrong, I appreciate Mendel and his contribution to genetics, but the exceptions seem much more interesting!</p>
<p>For example, many genes are pleiotropic, meaning they affect more than one phenotype. How about the recent development on red heads and anasthetics? I happen to live with a red head, from a long line of red heads, so in our family this was a topic of discussion for days. The mutation that causes red hair, also induces the production of a hormone that stimulates a brain receptor associated with sensitivity to pain. In short, if you have red hair, you are likely to need more Novacaine at the dentist.</p>
<p>Dentists supposedly have known this for ages. I wonder how many other interesting pleiotropies like this one have been observed, and are touted as old wives-tales (or dentist tales, as it were), but may actually have scientific validity?</p>
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